Between men and women there are no big quantitative differences as to progesterone secretion and serum progesterone levels (outside luteal phase and pregnancy). However progesterone is not only a sex hormone, it also belongs to the group of neurosteroids that are found at high concentrations in certain areas of the human brain. It can be synthesized within the central nervous system (CNS) and also serves as a precursor to other major neurosteroids.

Progesterone is reported to have neuroprotective and promyelinating effects which implies that it may be preventive to, but also may reverse, age-dependent changes and dysfunctions. Progesterone is further investigated as potentially beneficial in treating sleeping disorders, traumatic brain injury and multiple sclerosis.

  • Currently there are several registered progestreone products available; because of the poor bioavailability of progesterone when taken orally it must however be taken in high doses, it can be messy and hard to apply, patches might cause an allergic reaction and dosage might be difficult to control.
  • MetP Progesterone Nasal Gel bypasses the liver and intestines and therefore can be applied in much lower and safer doses, it is convenient, discrete and easy to apply.
  • In pre-clinical studies with MetP Progesterone Nasal Gel it was shown that the nasal route can provide relatively high brain exposure of the drug.