Dopamine has many important functions in the brain. Several severe diseases of the central nervous system are associated with dysfunctions of the dopamine system. Parkinson's disease is caused by loss of dopamine-secreting neurons in the substantia nigra. There is evidence that schizophrenia involves altered levels of dopamine activity, and the antipsychotic drugs that are frequently used to treat it have a primary effect of attenuating dopamine activity. Attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS) are also believed to be associated with decreased dopamine activity.

Dopamine is available for intravenous injection in the treatment of heart failure or shock. It cannot reach the brain; therefore, so far, the prodrug L-DOPA or dopamine-activating drugs have been used for treatment.

  • MetP Dopamine Nasal Gel is a new delivery form for dopamine. It will be the first product that effectively brings genuine dopamine into the brain offering potential for novel therapeutic approaches and minimizing the problems of L-DOPA and Ritalin treatment.